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Insulin Resistance CAUSES weight loss? May 12, 2009

Posted by Dr Dan in Uncategorized.
17 comments

I recently read this study by Weddick et al. from the American Journal of Epidemiology (Vol 153, no 12: 1199-1205) that I found very interesting. I will attempt to plagiarise sum it up here.

Overall the study investigates the paradox that on the one hand insulin resistance increases with old age, and on the other weight loss also tends to increase. The authors investigated the association between these two parameters among 725 nondiabetic men and women aged betweem 50-89 yrs old. Weight and insulin were measured at baseline (1984-1987) and evaluated again later (1992-1996). Insulin resistance was defined as the top quartile of fasting insulin levels and this quartile was found to be significantly associated with weight loss!!! Results remained the same for men vs women, overweight vs normal weight, and for young (< 70 yrs) vs old (> 70 yrs). Insulin-resistant individuals had a threefold increase likelihood of losing 10 or more kg compared to those without insulin resistance.

But why? We have always been told that insulin resistances causes weight gain not weight loss!!!! Yet other studies exist which show that insulin resistance is associated with weight loss.  Folsom et al. found evidence for high fasting insulin levels and low rates of weight gain in older adults (mean age 54 years) but not among young adults (mean age 25 years). Similar results have been found for Black women but not Black men. In Pima Indian children insulin resistance was found to predict weight gain but the opposite was found in young Pima adults. In Mexican Americans and non-Hispanic Whites higher fasting insulin levels were associated with a lower chance of weight gain. Thus, it seems that ethnicity could be important in the relationship between insulin resistance and weight gain. Several ideas have been put forward to explain this dilemma. The ‘thrifty genotype’ hypothesis suggests that those ethnicities genetically predisposed to diabetes also have higher levels of circulating insulin to promote fat storage during times of famine. This may work for the Pima children but falls apart with the adults and the other studies that showed that higher insulin levels were associated with lower rates of weight gain.

It has also been hypothesised that increased insulin resistance is a part of the ageing process, yet in this study the opposite pattern was observed. However, herein lies the secret. The oldest individuals were the LEAST insulin resistant and this was statistically significant! Therefore insulin resistance predicts mortality. i.e the least insulin resistant one is the longer they are likely to live independent of weight loss or gain. Yet weight does seem to have an influence. Increased insulin resistance with aging could be caused by an increase in visceral adiposity. Cefalu et al. showed that intraabdominal fat accounted for 51 % of the variance in insulin sensitivity. The authors in this study also found that insulin reistance was associated with less fat based on the waist:hip ratio.

I will discuss further explanations in the next few days.

A Question of Calories May 6, 2009

Posted by Dr Dan in Uncategorized.
Tags: ,
8 comments

I have been pondering lately whether my calorie intake is too low. I know this is going to attract a plethora of comments about how calories don’t matter. But if they don’t then surly it doesn’t matter how low my calories are as long as I am getting adequate nutrition – which I am.

The fact is I am happy with what I am eating and my hunger levels are somewhat in control. BUT if calories do matter then maybe I am going to low. I have had many comments about this in the past. My main argument is the whole research based around calorie restriction and how it can significantly increase longevity in a number of animals. This isn’t mean lifespan either but maximum lifespan. So at the moment my position is I don’t care that my calories are low because I know I am getting plenty of nutrients despite it.

But I would like to hear from people who may have their own opinions. I want to investigate this further throughout the week so I guess I am trawling for ideas that maybe I havn’t thought of.

Comments?

In addition, I just read this post over at Entropy Production. Definitely worth a read and very well put together.

Rebuttal for Red Meat Study May 5, 2009

Posted by Dr Dan in paleo diet.
Tags: ,
5 comments

 

I recently read this post at Health Habits regarding a study that showed increased risk of mortality with increased meat consumption. Naturally I wanted a chance of rebuttal. Here it is…

First of all I thought I better sum up the study. Researchers at the National Cancer Institute in the USA tracked 500,000 people aged 50-71 years for a 10 year period. Five groups were defined and ranked on meat consumption. The studies findings showed that the highest ranked group (i.e. biggest meat eaters – approx 62.5g per 1000 cals a day) had a modestly increased chance of dying, contracting heart disease and cancer compared to that group that ate the least amount of meat (approx 9.8g per 1000 calories per day).

This study has been widely cited on the internet and a lot of noise is been made to clamp down on meat consumption. My major problem with this study is they have not seperated out processed meats from grass fed meats. There is a BIG difference between eating a hamburger pattie from a grain fed cow and eating a steak from a grass fed cow. In fact many studies show links between processed meats and heart disease, cancer, etc but no study that I know of has shown any link between grass fed beef and increased heart disease or cancer. Such a study of course would be almost impossible because your typical ‘red meat eater’ does not cut out processed meats. Even in countries like New Zealand where meat is all grass fed it is also still processed. So seperating red meat eaters from processed meat eaters is impossible and very misleading when you read a study that says that eating red meat is bad for your health.

It is also interesting that the statistical differences were between the two extremes – biggest meat eaters vs smallest meat eaters. The difference did not increase along a gradient. The group eating the most meat are probably also big on eating lots of processed carbs, such as hamburger buns, fries etc. The group eating the least meat I would suspect are likely to be more concerned about their health, and also consume a higher rate of unprocessed foods such as vegetables.  So are these differences really to do with meat intake at all? I would certainly suggest that been a vegetarian that eats unprocessed foods is more healthy than eating hamburgers and hot dogs. Until a study comes out that specifically isolates grass fed meat from processed meat, and then still shows a higher rate of mortality in the meat eating group, I will be completely dismissive of such studies.

The group that also ate the least meat ate the most fibre. This was linked with a decrease in colectoral cancer and of course lots of fibre was considered to be the reason for this. However, Australians eat a higher amount of fibre than Americans but show higher rates of colectoral cancer also. So is fibre the cause? The problems with such studies is that there are so many variables and its almost impossible to isolate them. Therefore, they should be taken with extreme caution. I remember reading a study in New Zealand, which also showed that the white population ate a higher amount of meat and this was linked with higher incidences of stomach cancer than polynesian groups. Of course the white population also ate more vegetables and are we going to claim that vegetables cause cancer? This little titbit of information just happened to be mentioned ever so briefly and glossed over. As I said….too many damn variables.

 

Paleo Work Week May 1, 2009

Posted by Dr Dan in paleo diet.
6 comments

Im sorry everyone for my lack of posts. But I decided a couple of weeks ago that I needed a mental mind break to just focus on the paleo diet. I was becoming a bit mentally stressed having to think of things to write everyday and wasn’t focusing on the central issue which of course is my health. Funnily enough it really worked. I have been strictly (and I mean strictly) sticking to the paleo diet. In fact, I have eliminated a large proportion of saturated fats from my diet and have aligned myself more to the Dr Loren Cordain version. From my personal experience (and I emphasise personal) when I eat saturated fats in large proportions I feel lethargic, less energetic, less mentally healthy and I also get really hungry. Once these were reduced and replaced with olive oil I have returned back to what I used to feel like when I started paleo - full of energy, healthy and with mental clarity. In addition, the weight has started dropping off dramatically again. Im not here to trash saturated fats and I know that some people are fine on them. So I repeat this is what I have found works for ME.

So what does my current diet look like you might be asking? You probably don’t care but since your reading this blog Ill assume you do. I think I have developed my perfect diet plan for a working week when you have little time to cook but wanna eat paleo. Food can easily be substituted and you get far more nutrients than you could desire. Here is the breakdown of the macronutrients.

  Grams Calories %-Cals  
Calories  
2,163
   
Fat
134.6
1,171
54
%
Saturated
22.3
196
9
%
Polyunsaturated
19.6
169
8
%
Monounsaturated
81.5
707
33
%
Carbohydrate
84.0
309
14
%
Dietary Fiber
28.4
     
Protein
167.4
683
32
%
Alcohol
0.0
0
0
%

Here is a breakdown of the micronutrients:

      RDA % RDA
Vitamin A
8,332.1
mcg
900.0
926
Vitamin A
35,015.3
IU
Vitamin B6
3.9
mg
1.3
301
Vitamin B12
95.7
mcg
2.4
3,986
Vitamin C
220.3
mg
90.0
245
Vitamin D
8.4
mcg
5.0
167
Vitamin D
334.4
IU
Vitamin E
32.0
mg
15.0
213
Vitamin E
47.7
IU
Calcium
481.8
mg
1,000.0
48
Cholesterol
1,274.2
mg
Copper
16.6
mg
0.9
1,846
Iron
27.7
mg
8.0
346
Magnesium
462.1
mg
420.0
110
Manganese
3.4
mg
2.3
147
Niacin
40.2
mg
16.0
251
Pant. Acid
12.2
mg
5.0
244
Phosphorus
2,072.9
mg
700.0
296
Potassium
4,625.5
mg
4,700.0
98
Riboflav
5.6
mg
1.3
431
Selenium
234.7
mcg
55.0
427
Sodium
1,734.7
mg
1,500.0
116
Thiamin
1.4
mg
1.2
114
Water
1,036.4
g
Zinc
27.1
mg
11.0
247

So apart from the calcium everything seems fine. In most cases MORE than fine. So here is my work week food programme.

Breakfast (8am) – 2 eggs (cooked however) 

Morning Snack (10am) – Cup of Grapes or Berries

Lunch (1.30pm) – Seafood, Avocado, Spinach, Olive Oil, Green Vegetables, one other type of vegetable

Afternoon Snack (4pm) – Nuts

Dinner (6pm) – Red meat, serving of green vegetables, one other type of vegetable

Supper (9pm) – 100g of organs (liver usually) with some green vegetables.

You might notice that the carb intake is higher been up around 85g a day. This could be higher somedays where I might have some extra veges such as carrots, and so it may average around 100g a day. Interestingly I feel fine and I think that a little bit of carbs actually helps to boost my energy levels. My hunger cravings are completely manageable and I feel like I did when I first started which is a good thing.